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Molekulare Organization von Nanocarriern entschlüsselt

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Molekulare Organization von Nanocarriern entschlüsselt

Wirkstoff-Forschung
Analyzes nano-efficiencies for drug transport




Quelle: Pressemitteilung Ludwig-Maximilians-Universität München

2 minutes Lesedauer

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RNA therapies for transport in Zielzellen have been developed. Cationic Polymer is an effective product. Research in Munich now has the molecular organization that Nanocarrier entschlüsselt.

Olivia Merkel has developed a newly developed nano-transport system, with the medical treatment carried out locally. (Image: Florian Generotzky/LMU)
Olivia Merkel has developed a newly developed nano-transport system, with the medical treatment becoming available locally.

(Photo: Florian Generotzky/LMU)

The team is equipped with various air defense strategies to ensure safe transport: the protective membranes are designed to ensure safe transport, which are ideal for the end ring areas. Normally one of the most important Schutzmechanism used the Verabreichung von Medikamenten for the Schwierigkeiten. Schließlich sollen die Wirkstoffe and bestimmte Regionen im Körper gelangen, wofür sieft speziell präpariert bzw. were “packaged”.

Cationic Polymer is one of the most common working sows for the Transport of RNA therapeutics or RNA impact substances The lipid nanocarrier with mRNA impacting agents was invoked. The nanocopy packaging materials are effective in shaving and in the soul of paints in the low age. “Wir set Genfähren here, in that man all possible therapeutic Nukleinsäuren can be brought about, to ensure that they are undamaged and the Wirkort zu alles”, explains Professor Olivia Merkel, Inhaberin des Lehrstuhls für Drug Delivery an der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität Munich (LMU).

Trotz Valererfolge in der Research ist Krebs often not healthy. The new Hoffnung gives a Wirkstoff, a Sauerstoff can offer an unreachable Krebszellen solution. (Symbol image) (Image: free lizenziert)

Nanocarrier on the Spur

As the research becomes increasingly wordy, it is difficult to organize this article at the molecular level, encapsulating and releasing RNA – a question that has still not been fully explored. Merkel has conducted a new study into the organization of the Nanocarrier in the ERC-Forschungsprojekts RatInhalRNA (Rational and Simulation-Supported Design of Inhalable RNA Nanocarriers).

„Unsere Forschung nutzte aine Technik-naamen Coarse-grained molecular dynamics (CG-MD), an article that simulates and visualizes,” explains Forscherin. If the problem is in the fragmentation, there are problems in the polymer structure and the image wiring that matches the composition of the article. The simulations performed in laboratory experiments with nuclear magnetic resonance spectrocopy (NMR) are the best and most advanced, the CG-MD technology allows more detailed structure and representation of RNA nanoparticles. “The study of the CG-MD in the preliminary training and development of the properties of RNA nanoforms was the Entwicklung-besserer-systeme for such medical applications-understützen,” says Merkel.

Original publication: Katharina M. Steinegger, Lars Allmendinger, Sebastian Sturm, Felix Sieber-Schäfer, Adrian Philipp Eckart Kromer, Knut Müller-Caspary, Benjamin Winkeljann & Olivia M. Merkel: Molecular Dynamics simulations explain the molecular organization of poly(beta-amino- ester)-based Polyplexes for siRNA 3 Delivery. Nanoletters 2024; DOI: 10.1021/acs.nanolett.4c04291

(ID:50251737)

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