Simulations Plus optimizes business unit structure to support future growth following recent strategic acquisitions Page 1

Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”), a leading provider of biosimulation, simulation-enabled performance and intelligence solutions, and medical communications for the biopharmaceutical industry, today announced optimizations of its business unit and leadership structure to support future growth following the company’s recent acquisitions. These actions will be effective August 30, 2024.

“This past year, we completed two significant acquisitions, including the largest in our company history,” said Shawn O’Connor, Chief Executive Officer. “As a result, we have doubled our total addressable market, developed a unique platform, and significantly strengthened our talent pool. As we integrated Pro-ficiency into our platform, we identified synergies and opportunities to reorganize our business units and leadership structure to better serve our customers and maximize our growth opportunities. Most importantly, our extensive team of top industry talent is united by our shared mission to create value for our customers by accelerating the development and delivery of medicines to patients.”